Monitoring communicable diseases throughout South Africa and the African continent
Communicable diseases outbreak, and epidemic monitoring and response
Collect, analyse and interpret relevant data on communicable diseases

NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES

The national institute for communicable diseases (NICD)

Is a resource of knowledge and expertise in regionally relevant communicable diseases to the South African Government, to SADC countries and the African continent.

The NICD offers a variety of training programmes in the different areas of public health, including Field Epidemiology Training.

The Communicable diseases communiqué is published on a monthly basis for the purpose of providing up-to-date information on communicable diseases in South Africa. 

Developing young scientists as drivers of growth and innovation is vital in South Africa. This Youth Month we showcase some of our budding scientists. 

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JUNE COMMUNIQUE
Latest Information on Communicable Diseases in South Africa
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LATEST SCIENTIFIC PUBLICATIONS

AAV-mediated expression of broadly neutralizing and vaccine-like antibodies targeting the HIV-1 envelope V2 region
AAV-mediated expression of broadly neutralizing and vaccine-like antibodies targeting the HIV-1 envelope V2 region
HIV-1 infection continues to be a global health challenge and a vaccine is urgently needed. Broadly neutralizing antibodies (bNAbs) are considered essential as they inhibit multiple HIV-1 strains, but they are difficult to elicit by conventional immunization. In contrast, non-neutralizing antibodies that correlated with reduced risk of infection in the RV144 HIV vaccine trial are relatively easy to induce, but responses are not durable. To overcome these obstacles, adeno-associated virus (AAV) vectors were used to provide long-term expression of antibodies targeting the V2 region of the HIV-1 envelope protein, including the potent CAP256-VRC26.25 bNAb, as well as non-neutralizing CAP228 antibodies that resemble those elicited by vaccination.
Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan
Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan
The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class antibody development has been limited by the rare nature of these responses during natural infection and the lack of longitudinal sampling of such responses. To inform vaccine strategies, we mapped the development of a VRC01-class antibody lineage (PCIN63) in the subtype C infected IAVI Protocol C neutralizer PC063.
Analysis of risk factors associated with hepatocellular carcinoma in black South Africans: 2000-2012
Analysis of risk factors associated with hepatocellular carcinoma in black South Africans: 2000-2012
The aims of this study were to determine the prevalence of risk factors associated with hepatocellular carcinoma (HCC) in black adult South Africans and to estimate the size of the associated risks
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