Contact details:

Centre Secretariat

Secretary: Sexually Transmitted Infections
To be appointed

Carina Kriel
HIV Research section
email :

Monica Van Rensburg
HIV Molecular and Serology section

Prof Caroline Tiemessen
Cell Biology section

Professor Anna-Lise Williamson
HPV section


Surveillance/ Research Reports

National sentinel surveillance of STI syndromes aetiologies and HPV genotypes 2014-2015


Journal articles (47)

Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O’Keefe BR, Chikwamba R, Morris L.  Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. J. Virol. 2011; 17: 9039-9050

Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O’Keefe BR, Chikwamba R, Morris L.  The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the 2 DC-SIGN receptor and transfer to CD4+ cells.  Virology 2012, 423: 175-186

Auvert B, Marais D, Lissouba P, Zarca K, Ramjee G, Williamson AL.  High-risk human papillomavirus is associated with HIV acquisition among South African female sex workers. Infect. Dis. Obstet. Gynecol. 2011; 2011: 692012.

Bamford C, Brink A, Govender N, Lewis DA, Perovic O, Botha M, Harris B, Gelband H, Duse AG.  Surveillance activities.  South Afr. Med. J.  2011; 101: 579-582

Bonsignori M, Hwang K, Chen X, Tsao C, Morris L, Gray E, Marshall D, Crump JA, Kapiga SH, Sam NE, Sinangil F, Pancera M, Yongping Y, Zhang B, Zhu J, Kwong PD, O’Dell S, Mascola JR, Wu L, Nabel GJ, Phogat S, Seaman MS, Whitesides JF, Moody MA, Kelsoe G, Yang X, Sodroski J, Shaw GM, Montefiori D, Kepler TB, Tomaras GD, Alam SM, Liao H, Haynes BF.  Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors.  J. Virol. 2011; 85: 9998-10009

Coetzer M, Nedellec R, Cilliers T, Meyers T, Morris L, Mosier DE.  Extreme Genetic Divergence Is Required for Coreceptor Switching in HIV-1 Subtype C. JAIDS 2011; 56: 9-15

Crowther-Gibson P, Govender N, Lewis DA, Bamford C, Brink A, von Gottberg, Klugman K, du Plessis M, Fali A, Harris B, Botha M.  Human infections and antibiotic resistance.  South Afr. Med. J.  2011; 101: 567-578

Damelin LH, Paximadis M, Mavri-Damelin D, Birkhead M, Lewis DA, Tiemessen CT.  Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa.  J. Med. Microbiol. 2011; 60: 180-183

Dlamini JN, Hu Z, Ledwaba J, Morris L, Maldarelli FM, Dewar RL, Highbarger HC, Somaroo H, Sangweni P, Follmann DA, Pau AK.  Genotype Resistance at Viral Rebound among Patients who received Lopinavir/Ritonavir – or Efavirenz-Based First Antiretroviral Therapy in South Africa.  JAIDS  2011; 58: 304-308

El-Khatib Z, Ekström AM, Coovadia A, Abrams EJ, Petzold M, Katzenstein D, Morris L, Kuhn L.  Adherence and virologic suppression during the first 24 weeks on antiretroviral therapy among women in Johannesburg, South Africa – a prospective cohort study. BMC Public Health 2011; 11: 88

El-Khatib Z, DeLong A, Katzenstein D, Ekstrom AM, Ledwaba J, Mohapi L, Laher F, Petzold M, Morris L, Kantor R.  Drug resistance patterns and virus re-suppression among HIV-1 subtype C infected patients receiving non-nucleoside reverse transcriptase inhibitors in South Africa.  J AIDS Clinic Res. 2011; 2: pii 1000117

El-Khatib Z, Katzenstein D, Marrone G, Laher F, Mohapi L, Petzold M, Morris L, Ekström, AM.  Adherence to drug-refill a useful early warning indicator of long-term virologic and immunologic failure among HIV patients on 1st line ART in South Africa. PLOS One 2011; 6: e17518

Fayemiwo S, Müller EE, Gumede L, Lewis DA.  Development of a duplex PCR assay for the detection of plasmid-mediated resistance to penicillin and tetracycline in Neisseria gonorrhoeae.  Sex. Transm. Dis. 2011; 38: 329-333

Firnhaber C, Sello M, Maskew M, Williams S, Schulze D, Williamson A-L, Allan B, Lewis D.  Human papillomavirus (HPV) types in HIV seropositive men with genital warts in Johannesburg, South Africa.  Int. J. STD and AIDS 2011; 22: 107-109

Firnhaber C, Azzoni L, Foulkes AS, Gross R, Yin X, Van Amsterdam D, Schulze D, Glencross DK, Stevens W, Hunt G, Morris L, Fox L, Sanne I, Montaner LJ.  Randomized Trial of Time-Limited Interruptions of Protease Inhibitor-based Antiretroviral Therapy (ART) vs. Continuous Therapy for HIV-1 infection.  PLOS One  2011; 6: e21450

Gray ES, Madiga MC, Hermanus T, Moore PL, Wibmer CK, Tumba NL, Werner L, Mlisana K, Sibeko S, Williamson C, Abdool Karim SS, Morris L and the CAPRISA 002 study team. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection. J. Virol. 2011; 85: 4828-4840

Gray ES, Moody MA, Wibmer CK, Chen X, Marshall D, Amos J, Moore PL, Foulger A, Yu J, Lambson B,  Abdool Karim S, Whitesides J, Tomaras GD, Haynes BF, Morris L, Liao H. Isolation of a monoclonal antibody targeting the alpha-2 helix of gp120 1 representing the 2 initial autologous neutralizing antibody response in an HIV-1 subtype C infected individual. J. Virol. 2011; 85: 7719-7729

Hong HA, Loubser AS, de Assis Rosa D, Naranbhai V, Carr W, Paximadis M, Lewis DA, Tiemessen CT, Gray CM.  KIR genotyping and HLS KIR-ligand identification by real-time PCR.  Tissue Antigens 2011; 78: 185-194

Hunt GM, Coovadia A, Abrams EJ, Sherman G, Meyers T, Morris L, Kuhn L.  HIV-1 drug resistance at antiretroviral treatment in children previously exposed to single-dose nevirapine. AIDS 2011; 25: 1461-1469

Jansen van Vuuren P, Tiemessen CT, and Paweska JT. The role of anti-nucleocapsid protein immune responses in counteracting pathogenic effects of Rift valley fever virus infection in mice. PLOS One 2011; 6: e25027

Kuhn L, Coovadia A, Strehlau R, Martens L, Hu C, Meyers T, Sherman G, Hunt G, Persaud D, Morris L, Tsai W, Abrams EJ.  Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial. Lancet Infect. Dis. Published online March 16, 2012

Leichliter JS, Paz Bailey G, Friedman A, Habel MA, Vezi A, Sello M, Farirai T, Lewis DA.  ‘Clinics aren’t meant for men’: sexual health access and seeking behaviours among men in Gauteng province, South Africa.  SAHARA J. 2011; 8: 82-88

Leichliter JS, Lewis DA, Sternberg M, Habel MA, Paz-Bailey G.  Health care seeking among men with genital ulcer disease in South Africa: correlates and relationship to HIV-1 and HSV-2 detection and shedding.  Sex. Transm. Dis. 2011; 38: 865-870

Lewis DA.  HIV/STI epidemiology, management and control in the IUSTI-Africa Region: focus on sub-Saharan Africa.  Sex. Transm. Infect. 2011; 87: ii10-ii13

Lewis DA, Lukehart SA.  Emerging drug resistance in Neisseria gonorrhoeae and Treponema pallidum.  Sex. Transm. Infect. 2011; 87: ii39-ii43

Lewis DA.  Antimicrobial resistant gonorrhoea in Africa: an important threat to public health in need of a regionally-based gonococcal antimicrobial surveillance programme.  South Afr. J Epi. Infect. 2011; 26: 215-220

Lewis DA. Cefixime is first-line treatment for gonorrhoea in South Africa.  South Afr. J. Epidemiol. Infect. 2011; 26: 103-104
Lewis DA, Chirwa T, Msimang V, Radebe F, Kamb M, Firnhaber C. Screening asymptomatic individuals for genital discharge pathogens at a HIV treatment centre in Johannesburg: patient characteristics and pathogen prevalence.  Sex. Transm. Dis. Published online February 2012, doi 10.1097/OLQ.0b013e31824cbecc
Li J, Lipscomb JT, Wei X, Martinson NA, Morris L, Heneine W, Johnson JA.  Detection of Low-Level K65R Variants in Nucleoside Reverse Transcriptase Inhibitor-NJaive Chronic and Acute HIV-1 subtype C infections.  J. Infect. Dis. 2011; 203: 798-802

Lissouba P, Taljaard D, Rech D, Dermaux-Msimang V, Legeai C, Lewis D, Singh B, Puren A, Auvert B.  Adult male circumcision as an intervention against HIV: an operational study of uptake in a South African community (ANRS 12126).  BMC Infect. Dis. 2011; 11: 253

Moore PL, Gray ES, Sheward D, Madiga M, Ranchobe N, Lai Z, Honnen WJ, Nonyane M, Tumba N, Hermanus T, Sibeko S, Mlisana K, Abdool Karim SS, Williamson C, Pinter A, Morris L, and the CAPRISA 002 study.  Potent and broad neutralization of HIV-1 subtype C viruses by plasma antibodies targeting a quaternary epitope including residues in the V2 loop. J. Virol. 2011, 85: 3128-3141

Morris L, Chen X, Alam M, Tomaras G, Zhang R, Marshall D, Chen B, Parks R, Foulger A, Jaeger F, McParland M, Biliska M, Gray E, Abdool Karim S, Kepler TB, Whitesides J, Montefiori D, Moody MA, Liao H, Haynes BF.  Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B cell Sorting. PLOS One. 2011; 6: e23532

Mufhandu HT, Gray ES, Madiga MC, Tumba N, Alexandre KB, Khoza T, Wibmer CK, Moore PL, Morris L, Khati M.  UCLA1, a Synthetic Derivative of a gp120 RNA Aptamer, Inhibits Entry of the Human Immunodeficiency Virus Type-1 Subtype C. J. Virol. 2012 Feb 29 (Epub ahead of print)

Müller EM, Fayemiwo SA, Lewis DA.  Characterization of a novel beta-lactamase-producing plasmid in Neisseria gonorrhoeae: sequence analysis and molecular typing of host gonococci.  J. Antimicrob. Chemother. 2011; 66: 1514-1517

Müller EM, Venter JME, Magooa MP, Morrison C, Lewis DA, Napierala-Mavedzenge S.  Development of a rotor-gene real-time PCR assay for the detection and quantification of Mycoplasma genitalium.  J. Microbiol. Methods 2012; 88: 311-315

Paximadis M, Minevich G, Winchester R, Schramm DB, Gray GE, Sherman GG, Coovadia AH, Kuhn L, Tiemessen CT. KIR-HLA and maternal-infant HIV-1 transmission in sub-SJ. Infect. Dis. aharan Africa. PLOS One 2011; 6: e16541

Paximadis M, Mathebula TY,  Vardas E , Colvin M, Gentle N, Gray CM, Tiemessen CT, Puren A. (2012). HLA Class I (A*, B* & C*) and II (DRB1*) diversity in the Black and Caucasian South African population. Human Immunology 2012; 73: 80-92

Ramsay M, Tiemessen CT, Soodyal H. Review: Africa: The next frontier for human diseases gene discovery. Human Molecular Genetics 2011; 20(R2): R214-20

Ross JDC, Lewis DA.  Cephalosporin resistant Neisseria gonorrhoeae: time to consider gentamicin?  Sex. Transm. Infect. 2012; 88: 6-8

Taylor BS, Hunt G, Abrams EJ, Coovadia A, Meyers T, Sherman G, Strehlau R, Morris L, Kuhn L.  Rapid development of antiretroviral drug resistance mutations in HIV-infected children initiating protease inhibitor-based therapy less than 2 years of age in South Africa   AIDS Res. Hum. Retro. 2011; 27 (9):945-956

Tomaras GD, Binley JM, Gray ES, Crooks ET, Osawa K, Moore PL, Tumba N, Tong T, Shen X,, Yates NL, Decker J, Wibmer CK, Gao F, Alam SM, Easterbrook P, Abdool-Karim S, Kamanga G, Crump JA, Cohen M, Shaw GM, Mascola JR, Haynes BF, Montefiori DC, Morris L.  Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-infected Individuals. J.Virol. 2011; 85: 11502-11519

Tiemessen CT, Paximadis M, Minevich G, Winchester R, Shalekoff S, Gray GE, Sherman GG, Coovadia AH, Kuhn L. Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C of the C1 allotype. JAIDS 2011; 57: 181-189

Tiemessen CT. Commentary: The quest to understand protective immunity to HIV-1 through studies on maternal-infant HIV-1 transmission. South Afr J Epidemiol Infect 2011; 26: 205-209

Vandepitte J, Müller E, Bukenya J, Nakubulwa S, Kyakuwa N, Buvé A, Weiss H, Hayes R, Grosskurth H. Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda.  J. Infect. Dis. 2012; 295: 289-296

Venter JME, Müller EE, Maseko VD, Lewis DA.  Is the new variant Chlamydia trachomatis present in South Africa?  South Afr. J. Epidemiol. Infect. 2011; 26: 36-37

Weiss HA, Paz-Bailey G, Phiri S, Gresenguet G, LeGoff J, Pepin J, Lewis DA, Belec L, Hoffman I, Miller WC, Mayaud P.  Episodic therapy for genital herpes in sub-Saharan Africa: a pooled analysis from three randomized controlled trials.  PLOS One 2011; 6: e22601

Zazzi M, Kaiser R, Sonnerborg A, Struck D, Altmann A, Prosperi M, Rosen-Zvi M, Peres Y, Schulter E, Boucher CA, Brun-Vezinet F, Harrigan PR, Morris L, Obermeier M, Perno CF, Phanuphak P, Pillay D, Shafer RW, Vandamme AM, van Laethem K, Wensing AM, Lengauer T, Incardona F.  Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study). HIV Med. 2011; 12: 211-218


Articles in books (1)

Overbaugh J, Morris L.  The antibody response against HIV. From Biology to Prevention and Treatment.  Cold Spring Harb Perspect Med 2011.  doi: 10.1101/ cshperspect.a007039