New specialised molecular techniques for Mycobacterium tuberculosis detection have now been integrated into the surveillance system to better define drug resistance mutation profiles and clonal strains, using whole genome sequencing (WGS), restriction fragment length polymorphism (RFLP) typing, spoligotyping and mycobacterial interspersed repetitive unit (MIRU) typing, all of which have become well established and are producing important findings. In addition, the centre is playing a leading role globally in the development and application of methods for drug resistance determination for new anti-mycobacterial agents, particularly bedaquiline.
- Surveillance of microbiologically confirmed TB in South Africa
- Provincial and district-wide rifampicin resistance alerts for public health action
- Surveillance for bedaquiline resistance
- Prospective sentinel surveillance of RR TB, TB/HIV integration and hospitalised TB in South Africa
- Molecular epidemiological surveillance for early detection of RR clusters in selected districts