Sindbis fever is a febrile arthritis caused by infection with the Sindbis virus (SINV). SINV is an arbovirus that is transmitted to humans and other vertebrates via the Culex mosquitoes from birds, their normal reservoir. Sindbis fever occurs in Africa, Oceania and Eurasia. The virus was first isolated from Culex mosquitos in 1952 in Egypt. Human cases were first described in 1961 in Uganda, 1963 in South Africa and in 1967 in Australasia.