This report provides an analysis of recent reinfection trends, in order to improve situational awareness and inform resource planning by the Government of South Africa. 

Summary

• Since January 2021, we have conducted regular monitoring of reinfections in routine surveillance data to detect potential changes in reinfection risk, as may occur with the emergence of new variants
• We found no evidence that reinfection risk was higher as a result of the emergence of the Beta or Delta variants
• Reinfection risk increased substantially during the period of emergence of the Omicron BA.1 variant and plateaued at a level higher than associated with previous variants.
• Emergence of the BA.4 / BA.5 lineages was associated with a gradual increase in reinfections but trends remain consistent with what was observed for Omicron BA.1.
• This report includes analysis of data through 2022­11­29. The most recent data indicate that reinfections remain consistent with the level expected based on prior experience with the Omicron variant.

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